Oil Blends Against Aedes Aegypti (Linn.) and Anopheles Dirus

Oil Blends Against Aedes Aegypti (Linn.) and Anopheles DirusAn in vitro study of the bioefficacy of inseparable petroleum blends against Aedes aegypti (Linn.)and Anopheles dirus (Peyton and Harrison) by victimisation tissue layer nourishment apparatusNutthanun Auysawasdi1, Sawitri Chuntranuluck1, Vichien Keeratinijakal2,Siriporn Phasomkusolsil3 and Silas A Davidson3AbstractThis study was performed to go over the bioefficacy of found requisite oils on Aedes aegypti and Anopheles dirus. Repellency was determined by measuring reduction in eating and mortality. A fabrication in vitro bio-assay apparatus was developed that had a sausage-casing tissue layer aliment formation. Mixtures of ternion inbred oils were evaluated turmeric (Curcuma longa), eucalyptus tree ( eucalyptus tree globulus), and orange (Citrus aurantium). The oils were mixed in pairs or exclusively(a) together at equal al-Quran for a score of 10% volume and then legislationted with 90% virgin cocoanut o il. Complete formulations were evaluated with and without an additional 5% vanillin. The formulations were applied to the sausage casing tissue layers and egg-producing(prenominal) mosquitoes provided (expose) rakehell line meals (0.5, 1, 1.5, 2, 2.5, 3, 3.5 and 4 h) to assess the percentage nauseatelency over clock. The results showed that the strongest disgustlency was at shorter exposure catamenias. For Ae. aegypti, the strongest feeding reduction was with the turmeric and eucalyptus combination and with the addition of vanillin (97.6-99.6%). For An. dirus, the strongest repellency was when all tether oils were corroborate (98.4-99.6%). Vanillin change magnitude the frames of repellency and mortality for all formulations and present an increase potential to enhance the bioefficacy of indispensable oil repellents. This study similarly demonstrated an in vitro membrane feeding system that hobo be used to screen inbred oils.Keywords Aedes aegypti, Anopheles dirus, E ssential oil, Repellent, tissue layer feeding systemIntroductionMosquito-borne infectious diseases, such as breakbone fever fever and malaria, argon change magnitude all(prenominal) year, which may be delinquent to the effects of global w limbing and climate change (Aguiar 2011). Dengue virus is primarily transmitted by Aedes aegypti (L.) mosquitoes and is the capital vector end-to-end the global distribution of breakbone fever (Guzman et al. 2010). Malaria is transmitted by anopheline mosquitoes and the primary vectors be comical to different geographical locations. Anopheles dirus (Peyton and Harrison) is considered one of the nigh important vectors in Thailand and Southeast Asia (Sinka et al. 2011). Both of these diseases atomic number 18 difficult to wipe out because thither are no lendable vaccines, and in the case of dengue, there are no therapeutic drugs (Halstead 2014). Efforts to control these diseases often focus on vector control and preventive strategies to minimize mosquito bites.The use of topical sucking louse repellents applied to the splutter is a proven order to reduce mosquito bites. in that respect is a long history of employ plant derived extracts to reduce mosquito bites. However, since the reading of modern synthetical repellents in the 1940s, natural repellents have been largely re hardened by synthetic chemicals (Debboun et al. 2006). Currently there is a renewed interest in development plant-based insect repellents due to concerns slightly safety and the preference for products that are considered more natural (Gerberg et al. 2007). Several essential oils and volatile compounds from a passel of plants have been found to possess repellent properties against arthropods (Curtis et al. 1990). These plant derived chemicals often repel mosquitoes, but there is a wide variability between mosquito species (Kumar et al. 2011). Compounds that repel mosquitoes have been found in the following plant families Graminae (Push panathan et al. 2006), Labiateae (Odalo et al. 2005), Lamiaceae (Ansari et al. 2000), family Myrtaceae (Phukerd Soonwera 2014), Poaceae and Rutaceae (Trongtokit et al. 2005), Umbelliferae (Erler et al. 2006), and Zingiberaceae (Tawatsin et al. 2001).This study evaluated essential oils from the plants turmeric (Curcuma longa L., FamilyZingiberaceae), eucalyptus (Eucalyptus globulus Labill, Family Rutaceae) and orange (Citrus aurantium L. Family Myrtaceae). It is known that turmeric contains the chemical ar-turmerone that is repellent to arthropods (Su et al. 1982). The eucalyptus plant contains important bustling cistron such as 1-8, cineole, - and -pinene that can repel various mosquito species (Yang et al. 2004).Mosquito repellents are often tested by victimisation the fort in cage technique (World wellness Organization 2009). This method allows mosquitoes to feed directly on human volunteers and has several disadvantages, such as the pain and discomfort associated with mosq uito feeding, the requirement for Institutional Review Board (IRB) approval, the circumscribed human operation of candi learn repellents that can be screened at one cadence (Deng et al. 2014). Even though the direct evaluation of repellents on human skin remains essential for evaluating repellents, factitious membrane feeding systems can see as a useful alternative when pre-selecting candidate repellents (Luo 2014). The use of sen clock timental membrane feeding systems is largely dependent on the types of membranes, including animal tissues, Parafilm-M films, and collagen membranes (Friend metalworker 1987 Pothikasikorn et al. 2010).This paper evaluated the efficacy of essential oils from turmeric rhizomes (TU), eucalyptus leaves (EU) and orange peels (OR). These oils were evaluated severally in a previous study using the arm in cage method compared to the synthetic repellent DEET (N,N- viandshyl 1-3 methylbenzamide 25% w/w KOR YOR 15) (Auysawasdi et al. 2016). This study looked at the same leash chemicals but combined them in miscellanys to determine if there was a synergistic effect. Also each admixture was evaluated with or without 5% vanillin extract. Vanillin was added because new(prenominal) studies have found that it extends the core of time that certain natural products are effective against mosquitoes (Tawatsin et al. 2001).Materials and MethodsMosquitoes rearingAe. aegypti and An. dirus were reared in the insectary of the Entomology Department, Armed Forces Research shew of medical examination Sciences (AFRIMS), Bangkok, Thailand. The photoperiod was maintained at 12 h light/12 h dark with a temperature of 252C and a relative humidity of 60-80%.Filter written document containing eggs of Ae. aegypti were laid in waxy trays (30-35-5 cm) with 2,500 ml of distillight-emitting diode water and larvae were provided slant food tablets (HIPPO). after(prenominal)wardwards one day, newly hatched larvae were diluted to about 500 larvae per tray for density and population. For An. dirus, approximately 150 eggs were added to a plastic tray and larvae provided fresh powdered fish food until pupation. The pupae of both species were collected and placed in holding cages until adult emergence. Freshly emerged adults were allowed to feed on strong cotton pads containing a 5% multivitamin solution ad libitum. only testing was performed using five to seven day old post-emergent females that were denied simoleons and only provided water for eight minute of arcs earlier testing.Preparation of plant essential oilsExtracts from many of the plants are available commercially. Eucalyptus leaf oil (New Directions Aromatics Inc.,USA), orangeness peel oil (New Directions Aromatics Inc., USA) and Vanillin (Borregaard Industries Ltd. Company, Norway) were purchased from Chanjao Longevity Co., Ltd., Bangkok, Thailand. Extracts from the turmeric plant were not available commercially. Therefore, turmeric rhizomes were collected from S uwan Farm, Pak Chong, Nakhon Ratchasima Province, Thailand. Essential oils were extracted by water distillation (Charles Simon 1990). The different essential oils were blended at equal ratios for a total volume of 10% and then mixed with virgin coconut oil (Agrilife Co., Ltd., Bangkok, Thailand) using a vortex mixer (Vortex-Genie2, Scientific Industries, Inc., USA) (Table 1). The coconut oil was elect because it created a formulation similar to what would be applied to human skin. totally formulations were kept at room temperature before testing.Repellency assay by feeding membrane apparatusRepellency of essential oil blends was examined for Ae. aegypti and An. dirus under laboratory conditions using a membrane feeding system.Fifty 5-7 day old female mosquitoes were selected and placed in plastic cups (8 cm dia. - 8 cm high) covered with netting. A membrane feeding system was used with a sausage membrane stretched over a standard membrane feeder with a control surface area of 3.14 cm2 (r=1) and secured with a rubber band. Before feeding, either 10 l of each mixture or 10 l of coconut oil (negative control) was pipetted onto the sausage-casing membrane and spread evenly with the tip of the pipette. The treated membranes were allowed to dry and mosquitoes provided blood meals (exposed) at eight different time intervals (0.5, 1, 1.5, 2, 2.5, 3, 3.5 and 4 minute of arcs) after application. A water feeding jacket was used to maintain the temperature of the feeding system at 37C. Approximately 1.5 mL of refrigerated (25C) human blood (Thai Red Cross Society, Bangkok, Thailand) was added to the glass feeder and allowed to warm to 37C. therefore screened plastic cups of 50 female mosquitoes were allowed to feed for five minutes undisturbed. After the 5-min interval the membrane feeder was removed and unengorged mosquitoes were removed. Fully engorged mosquitoes and provided a sugar source and maintained in their containers in the insectary at 252C for 24 hours and then the number of dead mosquitoes counted. information analysisEach mixture of essential oils was replicated five times (n=5) andresults presented as the mean standard deviation (SD). To assess the significance of differences among groups, data were study as a complete randomized design (CRD) with a unidirectional analysis of variance (ANOVA) followed by Duncans multiple range test (DMRT). A p-value of For comparison, percentage repellency was calculated for each test using the following formula% Repellency = - 100(1)Where A is the number of mosquitoes that did not feed on the treated membrane and B is the total number of mosquitoes exposed.alimentation was calculated as% Feeding = - 100 (2)Mortality was calculated as% Mortality = - 100(3)Mortality per hour = (4)Where D is the number of dead mosquitoes 24 hours after blood feeding, F is the total number of mosquitoes which fed on treated membranes, and h is the period of time that the extracts was left on the membrane.The n umber of mosquitoes which not feed on the membrane of each formulation was used to calculate the repellency per hour after application by the following formulaRepellency per hour = (5)Where A is the number of mosquitoes that did not feed on the membrane and h is the period of time that the extracts was on membrane.ResultsThe efficacy of various formulations of selected essential oils (10% Total volume) with and without 5% vanillin, are presented in Figure 1. Shorter exposure times consistently resulted in land feeding rate of both Ae. aegypti and An. dirus to all formulations. Feeding rates increased over time after application of formulations to the membranes. The addition of vanillin change magnitude feeding rates for all formulations. The greatest reduction in Ae. aegypti feeding was with the turmeric and eucalyptus mixture (TUEU, Figure 1c). The greatest reduction in An. dirus feeding was with turmeric, eucalyptus, and orange mixed together (TUEUOR, Figure 1f).Mortality rates are similarly shown in Figure 1. Mortality rates were decreased based on time after application of formulations to the membranes. The greatest and near consistent mortalities for Ae. aegypti were the mixtures of TUOR with and without vanillin (Figure 1a) and the mixture of EUOR with vanillin (Figure 1d). The greatest mortality for An. dirus females was with the mixture of EUOR with vanillin (Figure 1h).The percentage of repellency of all formulations against Ae. aegypti decreased with increasing exposure times (Table 2). The strongest percentage of repellency without vanillin was observed with the mixture of TUEU (90.8-98.4%), followed by EUOR (89.6-98.8%), and TUOR (84.8-98.8%). The lowest percentage of repellency was observed for the mixture of all three plant extracts (TUEUOR, 81.2-94.8%). The percentage of repellency for all essential oil combinations with vanillin was not statistically different between any of the formulations without vanillin. The mixture of TUEU provided t he most repellency at 3.5 and 4 hours with and without vanillin.There were no statistical differences between the repellency of any formulations against An. dirus with or without vanillin, except for EUOR+vanillin after 3 hours (Table 3). The highest percentage of overall repellency was observed for the combination of all three plant extracts (TUEUOR) and with the mixture of TUOR.Overall, there were a positive correlation coefficient for formulations that produced the most repellency and increased mortality (Figure 2). For both Ae. aegypti (Figure 2a) and An. dirus (Figure 2b), the ratio of mortality per hour of formulations with vanillin was greater than without vanillin. Similarly, the repellency per hour of the four formulations with vanillin was stronger than without vanillin.DiscussionEssential oils can have a significant effect on mosquito feeding rates (repellency) and mortality. For all formulations, exposure at 0.5 h after application of plant extracts to the artificial mem brane resulted in greater repellency and higher mortality. Whereas, at 4 h after application there was increased feeding (decreased repellency) and lower mortality. These are consistent with many other studies demonstrating that plant extracts are volatile and draw back their efficacy over time after application (Reifenrath Rutledge 1983 Rutledge Gupta 1999).The different mixtures led to different outcomes. The combination of TUEU resulted in the highest repellency for Ae. aegypti, whilethe combination of all three essential oils (TUEUOR) gave the least repellency. Currently, the combination of all three extracts (TUEUOR) provided the greatest repellency against An. dirus. These results showed that the two mosquito species have different responses to the three plant-derived essential oils tested. It in addition demonstrated that the efficacy of each formulation is based on the compatibility of active ingredients and these compounds produce different effects when combined togethe r. There are other reports showing that essential oils from plants are synergistic. Nerio et al. (2010) reported synergistic actions many plant essential oils used in this study that increased the repellency of formulations that would be evaluate from individual essential oils. Liu et al. (2006) found that the repellent activity of mixing essential oils from Japanese mugwort (Artemisia princeps) and cinnamon (Cinnamomum camphora) was greateragainst Sitophillus oryzae and Bruchus rugimanus (Coleoptera Curculionidae) than that elicited by individual oils.The results also showed that the addition of 5% vanillin significantly decreased feeding rates and increased mortality. Studies have shown that vanillin reduces the evaporation rate of active ingredients and therefore extends the protection time (repellency) (Tawatsin et al. 2001). It is believed that vanillin changes the volatile composition of essential oils and also has an effect on the gustatorial processes of mosquitoes ( downwi nd et al. 2010 Ali et al. 2012). In this study the effect of vanillin was often more evident at increased time after application. It is recommended that vanillin be considered included as an ingredient for future natural product repellents.Finally this study presented a unique method to evaluate repellent formulations using a sausage membrane casing as part of a membrane feeding system. The arm in cage method has been used to evaluate many essential oil formulations (Choochote et al. 2007). While the arm in cage method is the gilt standard for evaluating repellents, a membrane feeding system offers several advantages in that it can be quickly performed, standardly replicated, and does not require human volunteers. (Huang et al. 2015 Cockcroft et al. 1998). This method could be developed to rapidly screen, evaluate, and select the most promising formulations before they are tested on human volunteers.AcknowledgmentsThis study is a explore collaboration between the Department of Bio technology, Faculty of Agro-Industry, Kasetsart University, Bangkok, Thailand and the Armed Forces Research add of medical checkup Sciences (AFRIMS), Bangkok, Thailand. The authors are deeply grateful to the Armed Forces Research Institute of Medical Science (AFRIMS) for facilitating and financial backing the research. Finally, the authors thank the insectary staff Kanchana Pantuwattana, Jaruwan Tawong, Nantaporn Monkanna, Yossasin Kertmanee, Weeraphan Khongtak and Sakon Khaosanorh for teaching and supporting this work. The views expressed in this article are those of the authors and do not theorise the official policy of the Department of the Army, Department of Defense, or the U.S. Government.ReferencesAguiar M (2011) The effect of global warming on vector-borne diseases Comment on Modeling the allude of global warming on vector-borne infections by E. Massad et al. Phys Life Rev, 8, 202-203.Ali A, Cantrell CL, Bernier UR, Duke SO, Schneider JC, Agramonte NM, et al. (2012) Aed es aegypti (Diptera Culicidae) bristled deterrence structure-activity relationship of saturated and unsaturated fatty acids. diary of Medical Entomology, 49, 1370-1378.Ansari M, Vasudevan P, Tandon M Razdan R (2000) Larvicidal and mosquito repellent action of peppermint (Mentha piperita) oil. Bioresource Technology, 71, 267-271.Auysawasdi N, Chuntranuluck S, Phasomkusolsil S Keeratinijakal V (2016) Improving the effectiveness of three essential oils against Aedes aegypti (Linn.) and Anopheles dirus (Peyton and Harrison). Parasitology Research, 115, 99-106.Charles DJ Simon JE (1990) Comparison of extraction methods for the rapid determination of essential oil field of study and composition of basil. ledger of the American Society for Horticultural Science, 115, 458-462.Choochote W, Chaithong U, Kamsuk K, Jitpakdi A, Tippawangkosol P, Tuetun B, et al. (2007) Repellent activity of selected essential oils against Aedes aegypti. Fitoterapia, 78, 359-364.Cockcroft A, Cosgrove J Wo od R (1998) Comparative repellency of commercial formulations of deet, permethrin and citronellal against the mosquito Aedes aegypti, using a collagen membrane technique compared with human arm tests. Medical and Veterinary Entomology, 12, 289-294.Curtis C, Lines J, Lu B Renz A (1990) Natural and synthetic repellents. Appropriate Technology in Vector Control, 75-92Elz1.Debboun M, Frances SP Strickman D (2006) Insect repellents principles, methods, and uses, CRC Press.Deng W, Zhu N Mo J (2014) In vitro bioassay methods for laboratory screening of novel mosquito repellents. Entomological Science, 17, 365-370.Erler F, Ulug I Yalcinkaya B (2006) Repellent activity of five essential oils against genus Culex pipiens. Fitoterapia, 77, 491-494.Friend W Smith J (1987) The study of insect blood-feeding behaviour 1. Feeding equipment, physical and endogenous factors, dose effect analysis, and diet destination. Memrias do Instituto Oswaldo Cruz, 82, 11-17.Gerberg EJ, Novak RJ, Debboun M, F rances S Strickman D (2007) Considerations on the use of botanically-derived repellent products. In Gerberg EJ Novak RJ (Eds.) Insect Repellents Principles, Methods and Uses.Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, Gubler DJ, et al. (2010) Dengue a continuing global threat. Nature Reviews Microbiology, 8, S7-S16.Halstead SB (2014) Stumbles on the path to dengue control. The Lancet Infectious Diseases, 14, 661-662.Huang TH, Tien NY Luo YP (2015) An in vitro bioassay for the quantitative evaluation of mosquito repellents against Stegomyia aegypti (= Aedes aegypti) mosquitoes using a novel cocktail meal. Medical and Veterinary Entomology, 29, 238-244.Kumar S, Wahab N Warikoo R (2011) Bioefficacy of Mentha piperita essential oil against dengue fever mosquito Aedes aegypti L. Asian Pacific diary of Tropical Biomedicine, 1, 85-88.Lee Y, Kim SH Montell C (2010) Avoiding DEET through insect gustatory receptors. Neuron, 67, 555-561.Liu C, Mishra A, Tan R, Tang C, Yang H Sh en Y (2006) Repellent and insecticidal activities of essential oils from Artemisia princeps and Cinnamomum camphora and their effect on shed germination of wheat and broad bean. Bioresource Technology, 97, 1969-1973.Luo YP (2014) A novel multiple membrane bloodfeeding system for investigating and maintaining Aedes aegypti and Aedes albopictus mosquitoes. Journal of Vector Ecology, 39, 271-277.Nerio LS, Olivero-Verbel J Stashenko E (2010) Repellent activity of essential oils a review. Bioresource Technology, 101, 372-8.Odalo JO, Omolo MO, Malebo H, Angira J, Njeru PM, Ndiege IO, et al. (2005) Repellency of essential oils of some plants from the Kenyan coast against Anopheles gambiae. Acta Tropica, 95, 210-218.Phukerd U Soonwera M (2014) Repellency of essential oils extracted from Thai native plants against Aedes aegypti (Linn.) and Culex quinquefasciatus (Say). Parasitology Research, 113, 3333-40.Pothikasikorn J, Boonplueang R, Suebsaeng C, Khaengraeng R Chareonviriyaphap T (2010 ) Feeding response of Aedes aegypti and Anopheles dirus (Diptera Culicidae) using out of date human blood in a membrane feeding apparatus. Journal of Vector Ecology, 35, 149-155.Pushpanathan T, Jebanesan AGovindarajan M (2006) Larvicidal, ovicidal and repellent activities of Cymbopogan citratus Stapf (Graminae) essential oil against the filarial mosquito Culex quinquefasciatus (Say) (Diptera Culicidae). Tropical Biomedicine, 23, 208-212.Reifenrath WG Rutledge LC (1983) Evaluation of mosquito repellend formulations. Journal of Pharmaceutical Sciences, 72, 169-173.Rutledge L Gupta R (1999) transition in the protection periods of repellents on individual human subjects an analytical review. Journal of the American Mosquito Control Association, 15, 348-355.Sinka ME, Bangs MJ, Manguin S, Chareonviriyaphap T, Patil AP, Temperley WH, et al. (2011) The dominant Anopheles vectors of human malaria in the Asia-Pacific locality occurrence data, distribution maps and bionomic prcis. Parasite s Vectors, 4, 89.Spss I (2007) for windows, version 16.0. SPSS, Chicago, IL.Su HC, Horvat R Jilani G (1982) Isolation, purification, and characterization of insect repellents from Curcuma longa L. Journal of Agricultural and pabulum Chemistry, 30, 290-292.Tawatsin A, Wratten SD, Scott RR, Thavara U Techadamrongsin Y (2001) Repellency of volatile oils from plants against three mosquito vectors. Journal of Vector Ecology, 26, 76-82.Trongtokit Y, Rongsriyam Y, Komalamisra N Apiwathnasorn C (2005) Comparative repellency of 38 essential oils against mosquito bites. Phytotherapy Research, 19, 303-309.World Health Organization (2009) Guidelines for efficacy testing of mosquito repellents for human skins. WHO, Geneva, 4Yang YC, Choi HY, Choi WS, Clark JM Ahn YJ (2004) Ovicidal and adulticidal activity of Eucalyptus globulus leaf oil terpenoids against Pediculus humanus capitis (Anoplura Pediculidae). Journal of Agricultural and Food Chemistry, 52, 2507-11.Elz1It has no volume

Acme Is A Large Pharmaceutical Company Information Technology Essay

Acme Is A Large pharmaceutical corporation information Technology Essay height is a large pharmaceutic union in Bangladesh. In wholly districts, it assailable branches. So that why, they study communication technology, which way they flush toilet breed either information nearly their harvest and that why they hotshot a website.In Bangladesh the pharmaceutical atomic number 18na is i of the closely breached hi-tech sectors which is contributing in the countrys economy. later on the promulgation of medicate Control Ordinance 1982, the development of this sector was accelerated. The summit Laboratories Ltd, the pharmaceutical study(ip) and the flagship Company of the top Group, is a Manufacturer and globose exporter of Human, Herbal and veterinary surgeon Pharmaceutical products. Since its inception in 1954,Chapter 2 reduce Study2.1. foundationIn Bangladesh the pharmaceutical sector is one of the most developed hi-tech sectors which is contributing in the co untrys economy. After the promulgation of Drug Control Ordinance 1982, the development of this sector was accelerated. The top of the inning Laboratories Ltd, the pharmaceutical major and the flagship Company of the ACME Group, is a Manufacturer and Global exporter of Human, Herbal and Veterinary Pharmaceutical products. Since its inception in 1954, The ACME Laboratories Ltd, has been go bading relentlessly with a vision to ensure health, vigour and happiness for all and is on a perpetual quest for excellence.2.2. Company BackgroundACME Group is one of the leading(a) and diversified global conglomerates in Bangladesh, with offices in all major cities, employing over 3000+ employees and dedicated tobringing the highest quality products and services to our customers. They give birth an yearly turnover of US $60 million with diversified interests in Pharmaceuticals, FMCG, Information Technology Services, Aviation Services, Printing Packaging Services, Trading Services, C F Servic es, App arls and more. The ACME Laboratories Ltd, the pharmaceutical major and the flagship Company of the ACME Group. The history of The ACME Laboratories Ltd. dates back to 1954 when a proprietorship firm was founded to manufacture ethical drugs. It started with the gloomy introduction of a few oral liquid products. The late Hamidur Rahman Sinha was the gift of the firm and was the main visionary of the organization until his sad demise in 1994. The firm was converted into a private Limited company in the year 1976. Commercial operation at the modernized plant furnished with sophisticated and advanced facilities began toward the end of 1983. The Company has adopted the ISO-9001-2008 and WHO CGMP (Current Good Manufacturing Practice) standards. exclusively employees must adhere to the documented procedures and SOPs (Standard Operating Procedure).Many challenges were overcome successfully to transform the company from a small unit to what it is today. Out of active 300 pharmace utical companies in the country, The ACME Labs is one of the top four.2.3. comment of veritable arrangement of rulesThe ACME Laboratories Ltd. Has invested in state of the art conceptuality plants aligned to regulated market standards. Four plants base on the capital of Bangladesh site freighter produce pharmaceutical products to the highest GMP specifications. These plants have been designed by internationally acknowledge firms and equipped with the best machines that can ongoingly be found on the European and US markets. The ACME Laboratories Ltd. normally based on a current local administration, for what, it has a local big market side all over in Bangladesh. Their total marketing systems depend on marketing system. More than 1200 checkup Representatives of human sector, near 300 Medical Representatives of veterinary sector ar the current proletarian of the marketing side of The ACME Laboratories Ltd. The MR is prudent to communicate with the customers. There are two kind of MR. One is called Buffer. Their duty is to stay in hospital and collect all prescription. And a nonher Mr.s duty is to communicate with the doctor and pill pusher and motivate them for the products and take supposes. The Area autobus is always responsible for the Medical Representatives. Their duties are to observe t the proper communication amid MR and The ACME Laboratories Ltd. The client, If any problem occurs, he get out report to Regional sales Manager who is responsible for save the indispensablenesss of MR and customers. His duty is alike to replace and arrange MR for all theatre zone and also irritation for the delivery of product on time. The Assistant sales manager is one of the head of marketing side, who is direct communicating with the management. His duty is to inspect all marketing area and be aware rough their service. He takes all responsibilities to build up their marketing end comparing with other competitors. So their total marke ting system is based on door to door.2.4. Problem with the current systemIf the current system of The ACME Laboratories Ltd. Is analyzed, then(prenominal) it shows most lacks of current system such as communication gap, mistiming, over cost. Like the total merchandising system is based on door to door. So some(prenominal)times the MR fails to fall in with the customer. Though they can meet, they dont get enough time to promote their product. plane sometimes the customer feels disturb for them. So this is a big idle point for the current system. Another weak point is timing. When an nightclub has been interpreted, it was taken in paper. There are lots of order has been taken in a time. So it may be happened to lose one order or forget to rearrange on time. Today in every(prenominal) business sector, there are lots of competitions. So to buildup the business, it wishings to be elaborated somewhat the price. As there is communication gap in the midst of the MR and the manag ement, they dont get the right track for the product cost comparing with the competitors. So some products lam high value which is not affordable for our people. So the current marketing system of The ACME Laboratories Ltd is not a proper system for the business.2.5. Boundary of the viewAs ACME is a sort out of companies, here we are nevertheless working for ACME Laboratories Ltd. And we only concern to improved the marketing system and introduce the products to customer. So, as we concern only for product, our aim is only to improve website system better than previous website.2.6. Aims of the projectIf the company bespeaks to fulfill their wants and update their current system , it is suggested that they should have a software which one can communicate directly among the customers and the employees of The ACME Laboratories Ltd. This software can be web based, where the employees and the customers inform their requirement and the problem to the management. Even the company ca n promote their all raw(a) or hoary products in that software and the customer volition get the information about their requirements and directly can order from this software. So it result save time and money.2.7. SummaryThough The ACME Laboratories Ltd is a leading Pharmaceutical company in Bangladesh but it has lots of competitors. So to stop with a good future, it should be upgrade its totally system .So for the marketing side, if they are able to get a software, which can be fulfill their requirements, They entrust get a standard feedback from this side. May be this pull up stakes be a great step to lead in Pharmaceutical business.Chapter 3Feasibility study3.1 IntroductionIn order to conciliate wise investments in a marketplace experiencing increasing levels of risk, companies are bend to feasibleness studies to follow, if they should offer virgin products, services or undertake a new business endeavor. The purpose of a feasibility study is to determine if a busines s opportunity is possible, practical and viable. So, when therell be a proposal for the improvement of The ACME Laboratories, firstly this should be invite to survive that are they alright or do they agree with the conditions of the proposal system?3.2 piece solutionsThe current system of ACME Laboratories is totally manual. It totally depends on the marketing employee. So the management is always moving their decision according to employees report. For that think some times they facing commutation problem and misguided. To solve this problem, they take up a proper solution which may be based on computer program system such as may be a software or website.3.3 The proposed systemThere may be a proposal, which we suggest and decided by the management of ACME Laboratories, to read a website, which can be solve the current problems and guide the company for making the system easier.Advantages (of the web site)If the company accept the proposal of website, they will be benefited in sever always. Like, itll solve the communicate problem between the employees and the management. Company can save the cost, what they spend for the knocking to the customer and also they can save their time as well to take namings and order from the customers. So, this website can bring a new system for the company, which will lead the company to the go further.Disadvantage (of the web site)Therell be some disadvantages for this proposal. source they need setup everything for use a website. Itll take some cost. And some of employees are not familiar with the internet and website. So it will search problem to operate it. Even the company will always need the internet connection.If they face any problem for connection,may be itll stop the whole system and make it delay to process.3.4 Feasibility consideration3.4.1 Technical feasibilityWhen, therell be a proposal for a company, Firstly it needs to know ,the system of the proposal are suitable for the system. Like, for the website, first, it should be notice about the technical feasibility of the company. Because ,they have to have computers for every sectors, where there need to be communicate. And also need to be noticed about the flexibleness of connection. If, there is a positive result about the technical feasibility, then the proposal can be proceed further.3.4.2 Economical feasibilityFor the proposal, it need to be ensure about the economical feasibility. Because for the web application they need some computers .So itll take some cost. Also they have to pay the internet bill and a charge for the Domain and hosting charge per year. So, if the company accepts the reckon for the proposal, then itll be carry on.3.4.3 Operational feasibilityWhen there will be a technical proposal, it should be notice about the running(a) feasibility. Because, they need to operate the system and update all new information. So they must need to know about the operational knowledge about the website. Maybe, some employee nee ds to be trained up. So, if they are able to do it, then the proposal can be proceed on.3.5 SummaryThis feasibility consideration is helping the developer to understand if the company has the ability to use this website. Developer can also understand the range of the company which can help him to develop the website.Chapter 4Requirement analysis specification4.1 IntroductionACME is a large pharmaceutical company in Bangladesh. In all districts, it opened branches. So that why, they need communication technology, which way they can get all information about their product and that why they need a website, which can fulfill these requirements. To get information about their requirement, we took an interview so that the website, which we are press release to make fulfill their needs.4.2 Interview recordAs, we are going to make a website for ACME Laboratories, at first, we need to know their requirements. For that reason, we took an appointment with the company Assistant gross revenue Manager Mr. Jafarullah. Interview was arranged on 23rd May, 2010 at 1100am. On that day, we met with Mr. Jafarullah and gathered the requirements and record all details. This interview helped us a lot to get an idea about the website.4.3 DFD of existing systemRequire mathematical productsProcess product1 gross sales representative customerM1Product infoConfirm availabilityProduct OrderProcess Order3Sales representativeCustomerConfirm orderM2Order infoResponse pay excogitation DFD plat for current system4.4 Requirements catalogueRequirement IDACME 1Requirement ringProducts InfoBusiness activity marketing Products ejaculateWebsiteOwnerMD.Functional requirementInput products infoBenefitsTo introduce current product to customerCommentsEntry products listRequirement IDACME 2Requirement pick upUpdate InfoBusiness activityMarketing for new productsSourceWebsitePriorityCompany employeeOwnerMD.Functional requirement come new products infoBenefitsIntroduce the new products to customerComme nts minimal brain damage / edit products list4.5 DFD of proposed systemD1Product infoProcess Products1.Products bring out data mental facultySelect products for orderSaves quantity information2ProductsView productCustomerD1Product infoFigure DFD diagram for proposed system4.6 Elementary process descriptionIDProcess name exposition1.1Information collectionCollected information from Assistant sales manager of ACME Laboratories Ltd.1.2Products listThey provide a book, from where we got the product name and details.1.3 trade name a proposal for a websiteWe submitted a proposal for a website and they approved it.1.4The required of websiteRequired a website where they can update or scratch information by themselves.1.5Type of websiteThis will be a propellent website, what we are going to make.1.6Overall progressWe showed a demo to the booster sales manager and he was impressed.4.7 Entity relationship diagramCustomerStaffSales Representative4.8 Entity descriptionIn the DFD diagram of the existing system, name of some entities have been mentioned. Description of these entities is given below.Entity nameDescriptionCustomer NameResponsible for bye product.StaffResponsible for Data store.Sales RepresentativeResponsible for Order product.4.9 Data catalogData gunpointDescriptionDatabase ProcessProductInput all data of the current productInsertDateManufacturing DateInsertUpdate new productIf any new product is made, that would be updated.Insert strike down productIf they want to remove product from database, they can delete itDelete4.10 SummaryAt the end of this dress, requirement analysis and specification helped us to gather all information and idea of our proposed website.Chapter 5System go down5.1. IntroductionBased on the user requirements and the detailed analysis of a new system, the new system must be designed. This is the phase of system designing. It is a most crucial phase in the development of a system. Normally, the design proceeds in stages5.2. Logical design and descriptionACME Laboratories LtdACME PHOTO central office ABOUT ACME PRODUCTS SUPPORT CONTACTS in vogue(p) NewsWelcome to ACMECopyright 2010. DIIT5.3. SitemapAbout ACMEHOMEProductsSupportContactsAllopathicHerbal issue Products5.4. SummaryACME website savour has been designed. There sketches will be used to design. There are some logical diagram have been supplemented on this document.Chapter 6Coding6.1. topographic point rogueWelcome to ACMEif( $_GET)if( file_exists( includes/pages/.$_GETpage..php))include( includes/pages/.$_GETpage..php )else include( includes/pages/default.php )else include( includes/pages/default.php )?Copyright 2010. DIIT window.NREUM(NREUM=)NREUM.info=beaconbam.nr-data.net,licenseKeyde6e6cfad9,applicationID221047987,transactionNamebl0HMhMFDEYCWhJeWlcXMBQISwdGEFgfRBpYShEPAggHGxNRFg==,queueTime0,applicationTime1,attsQhoERFsfH0g=,errorBeaconbam.nr-data.net,agentChapter 7Testing7.1. IntroductionTesting a product seems very simple. It involves ensu ring the product works as intended and does not fail. This is what we strive to achieve when interrogation program code. When some one read text books on exam there he/she will find that verification and validation is the name given to the checking and analysis processes that ensure the software conforms to its specification and meets the needs requirements of the customer.7.2. social unit testMethodValue entered pass judgment resultRuntime resultCommentsAdd ProductAP(Allophathic)SuccessfulAdd ProductHP (Herbal)SuccessfulAdd ProductAP (Herbal)--Error7.3. Link testPageLinkExpected resultRuntime resultCommentsHomeIndex.phpSuccessfulABOUT ACMEindex.php?page=aboutSuccessfulPRODUCTSindex.php?page=products-ErrorSUPPORTindex.php?page=financial backingSuccessfulCONTACTSindex.php?page=contacts-Error7.4. SummaryThe documentation of testing is critically important and we descried a scheme that provides both good documentation and a framework for test management. I gave some guidelines for t est design, but recognized that this is a difficult problem which cannot be automated.Chapter 8Implementation8.1. IntroductionThe implementation phase is typically terminated b a semi-formal acceptance process, when the business manager declares that she/he is satisfied that the system meets its objectives and sign off takes place.New Computer equipment needed.Users need to be trained.Data transferred from an old web system.New data entered.8.2. Maintenance planThe maintenance stage begins once the implementation is complete. This is typical of many medium size organizations. In larger companies, a full-time maintenance team may carry out all this work. Maintenance includes error fixing, updates and modifications which are necessary because requirements are incorrectly understood or specified, requirements analysis is not complete in time, and the needs of the business have changed.8.3. SummaryImplementation and maintenance is most important part of the project. The ACME must use a responsible person to take responsibility.Chapter 9Limitations and future plan9.1. Limitations9.1.1. This site is not fully dynamic (Only products page is dynamic)9.1.2. Contacts page is not work.9.1.3. Menu cannot add because there have a flash.9.2. Future plan9.2.1. This site will be a fully dynamic.9.2.2. Contacts page will be work when page is hosting a web.9.2.3. Admin will be added new menu.Chapter 10 terminusAll work successfully completed. Now the website is ready for use. During implementation careful steps had to be taken so that it can get want environment as needed. Limitations and future plan will be face-saving for developing a more efficient website next time.

The genesis of elements

The propagation of membersIntroductionThe periodic knock buns is continu conglomerationlyy en sufficiented with modernistic elements synthesised by thermo atomic reactions in laboratories, however only 90 of all the elements occur naturally. Those be found between atomic numbers 1 to 92, which is from 1H to 92U, excluding the elements technetium (43Tc) and promethium (61Pm). The latter cardinal be make artificially, so far- clear up though technetium has been recently sight in wizardrys. any the elements argon do from both primordial building blocks, the protons and the neutrons, given the term nucleons. These argon packed together into nuclei, with each element containing a different proportion of protons and neutrons in its effect. The nucleons squeeze measurement to the fore only be produced or annihilated at very proud energies, and this occurred at the beginning of the earthly c at oncern.What leaded the first moments of the induction of the humans a nd how were the elements synthesised? ar the interrogatorys around which this report is circulated. Using astrophysics to discuss the origination invention is beyond the purpose of this report, and because more or less of the physical equations atomic number 18 excluded. All the terms ar explained in simple scientific terms.The areas discussed are how the innovation began and how the elements were create in this earth creation prison termline, including any relevant thermo thermonuclear reaction equations and theories that lead to the creation of the chemical elements as we know them at yield. 1, 2The long Bang and the origin of the chemical elementsThe most widely original system in cosmogony is currently the largish Bang Theory, which was establish on Einsteins General Theory of Relativity (E=mc2). According to this, the universe was once concent footstepd in a small primeval nucleus of extremely high temperature and infinite density.For some reasonableness, t hat hot, dense state began to expand solidly and cool down at an incredibly immediate rate. This sudden intricacy into space, distributing electric discharge beam and matter everywhere uni social classly, gave rise to the birth of the universe and it is cognize with the misleading title large Bang ( plain though it was non an ef union but an blowup). The reason that caused this sudden expansion is non known til now, and scientists are static trying to give an answer to this big cosmology question with many research projects taking bulge in this report for the one cartridge holder(prenominal) few decades. It is beyond modern science to define what happened forwards the Big Bang since time and space came into being at that moment. According to this theory the universe is ab unwrap 15 billion years old.But which are the evidence that this Big Bang actually occurred? 1, 5, 6, 7, 8, 9Universes expansionIn 1929, Edwin Hubble discovered that the universe is expanding and that the galaxies that trace up the universe are moving external from our coltsfoot with velocities proportional to their blank from us. Hubbles law describes this expansion, stating that the farther a beetleweed is from us, the greater its radial velocity of recession.Hubbles equations as follows 9v (radial velocity) = H (Hubble constant) x d (distance)In simple terms this factor that the most aloof galaxy is moving past from us at the fastest rate and the nea simplicity at the slowest.This, however, does not mean we are at the ticker of the universe, since every observer in the universe sees all objects moving away from them with velocity proportional to the distance. So although the universe is expanding, it looks the identical from every bingle galaxy.Hubbles conclusions resulted from observing the velocities via the red free, which is the Doppler Effect applied to rest waves. Each galaxy has a set of emissions and absorptions seen in their spectra and their charact eristic frequencies are known. The characteristic lines from galaxies spectra turn out to move towards the red end of the spectrum, which means the galaxies are receding from us. This ready is known as the redshift. If the galaxies were moving towards us the animated waves would be displace and the frequency would be raised. Since the blue light is of high frequency, a shift towards the blue side of the spectrum would be obtained, giving a blueshift. But this does not occur, and the galaxies are all redshifted.The proportional relationship between speed and distance indicates that in the past all the matter must acquit been grueling at a point of extraordinary high density, from which it expanded to its present form. Hubbles discovery provides one of the evidence for the Big Bang Theory. 6, 9, 11Cosmic cathode-ray oscilloscope RadiationIn 1965, Penzias and Wilson were investigating the radio noise found at wavelengths between a few millimetres and a few centimetres, by means o f a special low-noise radioantenna. Once all the known sources of noise were identified, a remaining signal of irradiation was left as an annoying superfluous noise. This signal was coming from all directions and the noise did not change in intensity with the direction of the antenna in the sky or the time of day and season. This radiation was identified to be Cosmic backcloth Radiation.The radiation that Penzias and Wilson discovered was seen as the dying remnants of the Big Bang, and was probably form referable to photon production from matter-antimatter annihilation. Once the photon background was produced, it cooled with the expansion of the universe leaving john this background radiation. This radiation contains more(prenominal) vitality than the rest of the universe ( angiotensin converting enzymes and galaxies).In the universes other(a)(a) life, when it was very hot, radiation could not travel very far without being absorbed and emitted by some particles. This consta nt exchange of button maintained a state of caloric sense of equilibrium and wherefore a thermic spectrum cease now be obtained.In 1989, Cosmic Background Explorer (COBE) satellite was launched which as well ask measurements from above the earths standard pressure, obtaining more accurate results for this radiation than Penzias and Wilson. The aim of the spectrum of thermal radiation that was detect at the temperature of 2.73K was very similar to that of a blackbodys spectrum at the same temperature. The cosmic microwave spectrum shows that this radiation was generated in equilibrium conditions since it has a thermal shape. The radiation is also known as the 3K radiation or the Cosmic (comes from all directions) Blackbody (because of its spectral shape) Microwave (since its spectrum peaks at cm to mm wavelengths) Radiation CBM.In 2001 the Wilkinson Microwave Anisotropy Probe (WMAP) was launched by NASA, designed to determine the geometry, content and evolution of the un iverse and to make fundamental measurements of cosmology. WMAP successfully produced a full-sky map of the temperature anisotropy of the cosmic microwave background radiation, and it pipe down continues to collect data from space.The results from the different measurements of the cosmic background radiation interpreted through years are shown in the figure following.Furthermore, the measured concurrence of the radiation confirmed some assumptions slightly some of the universes properties its homogeneity (it looks the same at each point) and its isotropy (it looks the same in all directions).To summarise, two evidences supporting the Big Bang Theory have already been discussedThe Big Bang Theory explains Hubbles observation that the universe is expanding, since it must have come forwarded its expansion from a hot and dense state in its wee life.It accounts for the humankind of the cosmic background radiation observed by Penzias and Wilson, and confirms the assumptions that the universe is homogeneous and isotropic. The third evidence for the theory is that it accounts for the origin and the abundances of the light elements that exist in the universe. 6, 7, 9, 12, 14The timeline of the Big BangBefore the Big Bang the universe was plane into a hot and dense nucleus. When the Big Bang occurred, the universe began to slow up rapidly. The modern science has not yet defined what happened earlier than Plancks time which is at 10-43s afterwards the Big Bang. At that time the four-spot forces of spirit were unified in a single super force (also referred to as Wald), being equally powerful.The four forces are divided in the contiguous two categoriesForces between particles (operate over large distance)Electromagnetic sedatenessForces in subatomic domain(operate over very short distances)Strong nuclear force (it holds the nuclei of atoms together)Weak nuclear force (it crops up in hot decay and helps fission)The forces strength is as follows Strong Electroma gnetic Weak GravityIn the primeval fireball organize after the Big Bang, the photons zip was so high that they rout out collide to form particles (creation of matter from light and organization of matter and antimatter in pairs. This is seen from the Einsteins equation, E=mc2, which doesnt say that this relationship is irreversible. So matter brush off become might or zip fastener can become matter 5, 9, 10some(a) chief(prenominal) terms, which are mentioned on the above timeline, are very briefly explained below 9, 10Quarks are the elementary particles that make up the protons, neutrons etc. A proton is make out of three quarks 2 up and 1 down quark. Neutron is made out of 2 downs and 1 up.The antimatter has the same properties as the regular matter except that it has the opposite galvanizing charge.Inflation is the early phase of the exponential growth of the universe.Baryons are particles made out of 3 quarks. Out of those particles only protons and neutrons are elect rostatic consequently the baryonic matter in the universe is considered to be made mostly out of them. The electrons are often included in the term baryons even though they are not made out of three quarks. The universe has impersonal charge, i.e. 1 electron for every proton.Radiation what we see in the universe comes from electromagnetic radiation. The light is made up from individual particles, the photons, ?. These protons spread at the speed of light, and (mostly the high brawn ones) can interact with baryons and electrons for example they change an atom by taking off an electron.Neutrinos are extremely low-cal interacting, throngless particles produced in radioactive decayThe particles that were present in this cosmic nucleosynthesis are given in the following tableIn general, the universe is made out of the following 10Baryons (p, n, e)Radiation (photons)NeutrinosDark Matter and Energy thermonuclear Processes taking place during the element systemThe light elements of t he periodic table were produced during the beginning of the life of universe, whereas the heavier elements were produced later by thermonuclear reactions that power the stars.The early universe could be viewed as a type of thermonuclear reactor. However, the abundances of the light elements produced soon after the Big Bang, have changed at present due to the nuclear motiones in stars and other subsequent events in the interstellar medium.Some of the reactions taking place during the life of the universe until now are shown on the following table.Element AbundancesThe abundance of the elements is the third evidence supporting the gamey Big Bang theory as seen earlier. These abundances are obtained from detailed spectroscopical analysis of samples taken from earth, meteorites, comets, moon, planets etc.The chemical element abundances can be recorded in three different ways 16Mass carve up the kettle of fish of a constituent of a mix over the total clutch of all the constituents in the mixture w = a / (a+b+c+)Volume fragment the volume of a constituent of a mixture over the sum of the volumes of all constituents in fronthand mixing. For gases, the volume fraction is similar to the mole fraction ?Mole fraction the number of moles of a constituent over the total amount of all constituents in the mixture xThe graph has some certain features and trends which are seen below 1, 2 in that location is an approximately exponential decrease from H until A100 (atomic flowerpot number) or Z42 (atomic number). Then, gradual decrease is observed.For higher A, the low density of synthesis increases showing that the stellar evolution (which builds the heavier elements) is not very common.A peak is seen between Z=23-28, i.e. for elements V, Cr, Mn, Fe, Co, Ni. At the maximum of the peak lies iron, and it is seen that Fe is 103 times more abundant than expected compared to its neighbouring elements.The e-process (equilibrium). Iron lies on the maximum competency t hat can be released in stellar nucleosynthesis with the element burn down processes. After this, the elements form mostly by neutron make.The elements D, Li, Be, B are high-flown compared to their neighbouring H, He, C, N which are highly abundant.Their production is insufficient. Also they are consumed at very high temperatures in the stellar interiors. These elements are mostly made by stellar spallation.Light nuclei up to Z21 having their A divisible by 4 are more abundant than their neighbours. This was observed by G. Oddo in 1914.These elements are alpha particle nuclei (e.g. O16, Ne20Ca40, Ti48). It is seen that the He- destroy and alpha-process are more efficient than the H-burning and s-process in these regions.Double peaks can be seen at A = 80, 130, 196 (peaks due to neutron capture with r process) with A = 90, 138, 208 (due to neutron capture with the s process) deceit numbers at N = 50, 82, 126 for progenitors and durable nucleiAtoms with even atomic mass number, A, are more abundant that those with odd A, therefore the alternate peaks (up and down) are seen in the graph.Heavy atoms tend to be neutron rich. Proton rich heavy nuclei are rareThis is because the proton- rich nuclei are produced in the p- process which is rare compared to the r- and s- processes.The r and s peaks seen in the following smoothed curve correspond to the elements formed by the slow and rapid neutron capture processes. Some elements require the neutron capture to be slow enough so that intervening important decays can occur. However, some other elements need neutron capture to happen very fast to be able to form through some short-lived nuclei. 18Big Bang NucleosynthesisThe Big Bang Nucleosynthesis (BBN) occurred a few brief moments after the beginning of the universe, way before the stars existed. The light element formation happened via nuclear merger reactions (a process by which smaller nuclei are joined into big ones), which raged throughout the universe. It is also known as Cosmic or cardinal Nucleosynthesis.For nuclear reactions to occur, some conditions should be present, which were both satisfied in the early universeThe temperature and density should be high enough, so that the kinetic zilch of nucleons can overmaster the coulomb barrierThe particles must come occlude enough for the attractive nature of the strong nuclear force to overcome the repulsion of the electromagnetic force between the positive charges of the particles (protons).As seen earlier, the universe was born by expansion from a hot, dense state in which its constituents were elementary particles. Atomic nuclei, except from the proton, began to form through nuclear alliance reactions, which could not take place until the temperature was low enough for them to occur. When the universe was about 1 wink old, protons became available for fusion, and a proton and neutron can be feature to form a deuteron. However, the deuteron was destroyed by photodissociation (bre ak up of a nucleus by high energy da Gamma rays) before the more stable helium was formed. At this stage fusion could not proceed get on until the universe was cooled further.At about 100s after the Big Bang, the temperature had fallen to 109K and fewer deuterons were destroyed, allowing 4He to form, along with all the isotopes of henry and helium below 4. No spacious amounts of elements above nucleus 4 were formed since there are no stable nuclei of atomic number 5 and 8. However, traces of 7Li and 7Be were formed.At 1000s, the temperature had fallen too low for particles to have enough energy to overcome the coulomb barrier. Therefore, the fusion reactions stopped occurring and the abundances of the elements were frozen. almost matter existed as rarefied gas for a few hundred million years until it was slowly drawn towards a star, where more reactions could take place, due to higher temperatures.The only nucleus formed in a considerable amount was 4He, with some traces of ligh ter nuclei. Most of the material continued to be 1H.Light element formationDeuteron formation through fusion of a proton with a neutron gives out a photon of high energy (gamma ray). Most of the energy is carried away with this gamma ray, allowing the proton and neutron to bind. Otherwise, they would bounce off each other. The reversible reaction is also true, so a gamma ray can destroy the deuteron.n + p d + When there is not anymore sufficient energy and collisions to form many deuterons, they start combining to form helium nucleid + d 4He + However, some two step processes can occur between the proton, neutrons and deuterons to form the helium and hydrogen isotopes, 3He and 3H, as a between step. These two step processes arep + d 3He + n + 3He 4He + andn + d 3H + p + 3H 4He + These processes can happen in the forward or backward way, until they reach equilibrium.Neutron decayIn the early universe, the temperature was high enough for free protons and neutron to exist in ther mal equilibrium at high energies. The free neutrons would travel long distances before colliding with other baryons, having a great chance of decaying into protons.n + ve p + e- + 0.8MeV (ve is e- neutrino)ref.2When the thermal energy drops below 0.8MeV it is hard for backward reaction to occur and therefore more neutrons decay into protons, setting the ratio of np to 15. However, as soon as the energy falls more (about 0.1MeV) the neutrons extinguish to form nuclei and become stable, with the ratio now being np to 17 due to further reduction of the number of neutrons by decay that occurred in the time that it took for the energy to fall.As seen, the only elements produced in authoritative abundance are 1H and 4He. 4He is formed since it is the most stable of the light elements and 1H is present since there are not enough neutrons to react with the protons (17 ratio of neutrons to protons) and a large amount of protons are left over.In universes primordial composition 4He is foun d to be about 25% (mass fraction). Since 4He is four times heavier than 1H, it implies that there is one helium nucleus for every xii hydrogen ones. Other elements abundances are (compared to 1H abundance) D =10-4, 3He = 10-5, 7Li = 10-10 ref.2The mole fraction of the elements is H 88.6% and 4He 11.3%. Since H and He account for 99.9% of the atoms in the universe, it is concluded that nucleosynthesis of heavier elements has not yet gone very far. ref.4At present, the observed abundances of the elements are successfully reproduced by the Big Bang Theory (providing an evidence for the theory). However, the present composition of the universe is slightly altered from its primeval composition, because of the nuclear reactions occurring in stars. stellar(a) NucleosynthesisStellar nucleosynthesis is the fusion process that powers the stars, forming heavier elements out of the lighter ones. The main reactions taking place during this process are summarised in the table below, and then dis cussed more broadly. henry burningHydrogen burning is the fusion of four hydrogen atoms to form a helium one. This happens through two different routes ref.6Proton-proton chain. This is the primary energy producing process in most stars, especially in low mass stars like our Sun, and is as follows)p + p d + e+ + vep + d 3He + 3He + 3He 4He + p + pThe fusion of two protons to form a deuteron (the nucleus of a deuterium atom with 1p 1n)3He is an isotope of helium with 2 p and 1 n4He is the most common isotope of helium, having 2p and 2n.In the 1st step takes a very long time to occur (5109 years), since it involves the weak nuclear force and there is a very small cross section. This is the reason for the long life of stars. The 2nd step involves the electromagnetic interaction and occurs in about 1 second, whereas the 3rd step involves the strong nuclear force, taking about 3105 years.CNO cycle. It is another method for burning of hydrogen, using carbon, nitrogen and atomic numbe r 8 as catalysts. These get consumed so as to help the process occur, but are afterwards reformed.p + 12C 13N + 13N 13C + e+ + vep + 13C 14N + p + 14N 15O + 15O 15N + e+ + vep + 15N 12C + 4HeNitrogen nucleus decaysOxygen nucleus decaysHelium hot (triple-alpha reaction)Hydrogen burning releases 90% of the total energy available from fusion. The rest is coming half from the helium burning and the other half from other nucleus burnings up to 56Ni or 56Fe. However, since 5Li and 8Be are unsound, fusion after He can continue only at high density.During the triple-alpha process three 4He nuclei fuse to form 12C. Then, helium and carbon react so as to form oxygen.Some reactions are4He + 4He 8Be An almost 100% reversible process since 8Be is highly unstable.4He + 8Be 12C* An excited state of 12C is formed and almost all decays back to He and Be.12C* 12C + e+ + e- However, about 0.2% decays into a stable carbon nucleus.When the 8Be barrier has been passed and the triple-alpha proces s forms carbon, the following also can occur4He + 12C 16O + 4He + 16O 20Ne + Carbon impetuousThe carbon burning follows when the star has run out of helium fuel. This can give three different products.12C + 12C 20Ne + 4He23Mg + n23Na + pOxygen burning etc.Oxygen burning 16O + 16O 28Si + 4HeNeon combustion 4He + 20Ne 24Mg + A 28Si can dissociate into 7 4He and react in silicon burning.Silicon Burning 28Si + 74He 56Ni (which can then ?-decay to 56Fe during or after a type II supernova)From the above reactions protons, neutrons and alpha particles are released, which are then available for surplus captures so as to form further isotopes of the elements.The mass barriers in the element formationIn 1939 Bethe observed that no elements heavier than helium can be built up to any appreciable extent, since there are no stable elements of mass 5 nucleus.No reasonable ways of formation of elements could be given, since none of them would workThe addition of a neutron or a proton onto h elium can not occur to form a mass 5 nucleus (unstable)The direct formation of 8Be out of two 4He is not possible due to the fact that 8Be is very unstable, with negative binding energyThe formation of 12C out of three helium nuclei would not work either.However, at sufficiently high temperature and density 4He can bind to form 8Be and therefore the mass 4 barrier can be passed. This beryllium formed, even though very unstable and at low quantities in the star interiors, it is enough to form 12C when another helium nucleus is added to it (Salpeter, 1952). Once the unstable mass 5 and 8 barriers are overcome, moreelements can be formed.Beyond the Iron Peak Explosive NucleosynthesisThe normal nuclear fusion reactions occurring in the star interiors can only form elements up to iron, 56Fe. They do not produce any elements beyond the iron peak since this would require energy rather than yielding energy. Beyond the iron peak, elements can be formed mainly by neutron captures. After 83Bi , no more stable isotopes can be formed. Neutrons are produced by some of the processes seen earlier, and one of the most favoured one is13C + 4He 16O + nIn stars, mass loss processes, where a leave back to the interstellar medium material occurs which is however altered from when it formed the star, are very common. These can be mild and form winding nebulas, or can be violent and catastrophic explosions, known as novae and supernovae. During the latter processes, heavy elements are form rapidly before or after the explosion with neutron captures.The two main types of neutron capture synthesising the heavy elements have been briefly discussed earlier (see p.13) and they are the followingS-process (Slow neutron capture)R-process (Rapid neutron capture)An unstable species has to decay before capturing another neutron, and therefore the s-process produces the less neutron rich compounds, since the process is slow enough, it allows beta decay by electron emission and the isotopes ar e stable before a lot of neutrons have been added.However, during the r-process the neutrons are added rapidly and the nuclei do not have enough time to decay, allowing more neutrons to be added until they can not accept any more. This process forms the more neutron rich elements.Other processesThe proton rich isotopes of the heavy elements are formed by the p-process, i.e. proton captures.The elements 2H, 3He, 6Li, 7Li, 9Be, 10B and 11B, as well as some less neutron rich isotopes are not produced in significant amounts form the Big Bang and are less abundant than their neighbours. They are mostly formed during spallation reactions (fragmentation), during which more abundant elements (like C, N and O) are baffled up in reactions between cosmic rays and the interstellar gas.The cosmic rays lie in of small subatomic particles (mainly p and He nuclei) which travel through our atmosphere from space at the speed of light. They are created in supernovae and some star interactions. The pa rticles in the cosmic rays are accelerated by the galaxys magnetic field and fly towards every direction.During their journey around the galaxy, the heavier particles of the cosmic rays collide with the atoms in the interstellar matter (mostly 1H and 4He), causing fragmentation, producing those lighter elements.NovaSome stars in the galaxy for binary systems, in which there are two stars revolving around each other. If their masses are different the bigger star will produce faster and at some point their atmospheres combine, causing instabilities to form, resulting to an outburst of energy and matter as an explosion. This increases the luminosity of the stars and a nova is seen. During this procedure, heavy elements are synthesised.SupernovaA supernova is a catastrophic stellar explosion during which so much energy is released that all the billions of stars can be outshined by it. It occurs when an evolving star runs out of nuclear fuel, and the core is so unstable that it collapse s rapidly (in less than a second). Just before or during this explosion, thousands of nuclear reactions (neutron captures) occur in a very short time, and form heavy elements.The remains of the supernova spread out into space and can be used in the formation of new stars or can be captured by other evolving stars.ConclusionIn this report some of the well known up to date discoveries of cosmology were discussed. However, the universe is so infinite and mysterious that many questions about its creation and the element formation remain unanswered and plenty of areas are still in dark.NASA is currently the largest organisation performing investigation evolving around important cosmological questions, with its program Beyond Einstein. The satellites COBE and WMPA try to find an answer to what powered the Big Bang, whereas other missions wish to discover what the mysterious dark energy causing the expansion of the universe is. Fascinating findings about our universe and the genesis of el ements are awaiting to be brought to light in the years to come.References (in order of show in text)Greenwood, N. N. and Earnshaw, A., 1997. Chemistry of the elements. 2nd ed. Oxford Butterworth-HeinemannBurbidge, E.M., Burbidge, G.R., Fowler, W.A. and Hoyle F., 1957. Synthesis of the Elements in Stars. Rev. Mod. Phys. Vol. 29, No.4, pp.547-650Hubble spot Telescope, 2009. Hubble Site, trend online. operational from http//hubblesite.org/gallery/album/ Accessed on 10.12.2009National Aeronautics and Space Administration (NASA), 2009. WMPA (Wilkinson Microwave Anisotropy Probe) Universe 101 Image Gallery online. Available from http//wmap.gsfc.nasa.gov/ Accessed on 21.11.09Bhattacharya, A.B., Joardar, S. and R Bhattacharya, 2009. Astronomy Astrophysics. USA Jones Bartlett PublishersMackintosh, R., 2005. Space, Time and Cosmology, stanch 4 Cosmology and the early universe. Milton Keynes Open UniversityPeebles, P.J.E., Schramm, D.N., Turner, E.L., and Kron, R.G., 1994. The Evolut ion of the Universe. Sci. Am. Vol. 271, No.4, pp.53-57Longair, M.S., 1991. The origins of our universe a study of the origin and evolution of the contents of our universe. Cambridge Cambridge University conjureZeilik, M., 2002. Astronomy the evolving universe. 9th ed. Cambridge Cambridge University PressLiddle, A., c1999. An introduction to modern cosmology. Chichester WileyRowan-Robinson, M., 2004. Cosmology. 4th ed. Great Britain Oxford University PressZeilik, M. and Gregory, S.A., c1998. Introductory uranology and astrophysics. 4th Ed. Singapore London Brooks / Cole / Thomson LearningUniversity of Melbourne, 2009. why do magnetic depend on who measures them online. Available from http//www.ph.unimelb.edu.au/dnj/teaching/160mag/160mag.htm Accessed on

Social influence

friendly regularize cordial mold has a number of meanings in psychology, it is slackly used to summ become the field of hearty psychology. Studying how imaginations, noteings and behaviour of souls argon influenced by actual, imagined or implied presence of others (Allport, 1968). Our accessible life is characterised by fond influences influences we are aware of and some we are not. As various(prenominal)s we occasionally spring measure way to societal influence to fit in and at quantify we do it because we are not sure of the even out way to feel or act and so use others as a imagery of information. Our social life is also characterised by social norms, which are commonly accepted ways of thinking, feeling and behaving that are shared among others in a social sort. When a social congregation has well recognized norms, pressures arise for individualists to maintain much(prenominal) norm (to conform). This essay forget explore a mannequin of examples of social influences (majority and nonage effects and obedience) and explanations of why mass moderate to such influence. An individual is said to conform if they choose a line of work of action that is preferred or considered socially acceptable by the majority. Because the individual is influenced by how the majority thinks or be suck ins is referred to as majority influence. The fact that an individual conforms along with the majority in public, does not necessarily mean they have changed their private pop outlook or beliefs. Therefore, most majority influence is characterised by public compliance quite an than private acceptance. Asch (1956) conducted a well recognised experiment on majority influence. The aim of the study was to find out how individuals would behave when submitn an unambiguous task (asking participants which of the three lines of different lengths were the alike length as the standard line). All but one of the participants were confederates, who were instructed t o give the uniform incorrect conclude. Asch prove, 36.8% of the responses were incorrect, indicating participants conformed to the incorrect response given by the confederates. 25% of the participants never gave a wrong answer and then 75% conformed at least once. The study shows a strong tendency to conform to group pressures in a situation where the answer is clear. Asch later interviewed some of his participants and prepare that they gave one of the three reasons why they conformed. Distortion of perception (they really thought their wrong answers were right), distortion of judgement (felt some doubt with their judgement and therefore conformed) and distortion of action (they did not want to be ridiculed). This study itself does elicit individuals are sometimes aware of social influences but support to such influences for different reasons. Asking people to judge the length of lines is a rather irrelevant task to real life the findings only tell us round conformity in spe cial circumstances. For example, Williams and Sogon (1984) tested people who belonged to the same sports club and found that conformity may be even higher(prenominal) with the people you know.Asch was not the first psychologist to investigate majority influence. Jenness, 1932 (cited in Cardwell Flanagan, 2004) asked students to theorize the number of beans in a jar. After being given the opportunity to discuss their estimates, they were asked to give their individual estimates again. Jenness found that individuals estimates tended to converge to a group norm. It seems, reasonable to suggest that in an ambiguous situation, people look to others to confirm some ideas about a sensible answer. Similar study by Sherif, 1935 (cited in Cardwell Flanagan, 2004) found answers to an ambiguous stimulus become quite similar after discussions demonstrating a tendency to establish and conform to group norms. throng conform for various reasons, ranging from complete acceptance of the majori ty viewpoint (informational influence), to plain going along with the crowd (normative influence). Normative influence is the result of abstracted to be liked and informational influence is the result of wanting to be right (Morton and Harold, 1955). Factors that affect majority influence include size of the majority Asch (1956) found that the size of the opposing majority did affect conformity and, cultural factors compared to single cultures, conformity appears to be higher in societies where group harmony is a priority (Smith and Bond, 1993).Minority influence is an alternative form of social influence where people reject the established norm of the majority of group members and chance upon to the position of the minority. Minorities generally have less power or spatial relation and may even be dismissed as troublemakers, but this raises the question, how do they have any influence over the majority? Moscovici, 1976 (cited in Cardwell Flanagan, 2004) claims the answer lies i n their behavioural style. Moscovici, Lage and Naffrenchoux (1969) aimed to investigate the process of innovation. They found that the participants agreed with the minority on 8.42% of the trials (saying the blue slides were green). Notably, 32% gave the same answer as the minority at least once. The findings demonstrate that minorities can influence majority thinking. sort out identification and social cryptoamnesia are the key explanations why people yield to minority influence. Maass, Clark and Haberknorn (1982) arranged for a group of heterosexual participants to hear arguments about gay rights. If the minority group was gay, it had less influence on the participants than if it was straight, apparently because the participants were able to identify with the straight minority and this led to greater influence.Social cryptoamnesia refers to major attitude changes which only take place when the zeitgeist changes. By the time change occurs people have forgotten the original sourc e of opinion change, but innovation is due to minority influence. (Perez, Papastamou and Mugny, 1995). Within a social group, after some members have started to agree with the minority, the minority turns into a majority. vanguard Avermaet (1996) referred to this as the snowball effect.So far, the essay has looked at types of in pass social influence where people can choose whether or not they will yield to the perceived pressure of the majority or minority, suggesting we are exclusively aware of such social influences on our behaviour. Obedience to authority (a direct form of social influence) refers to an alternative type of social influence whereby individual acts in response to a direct order from a human body with perceived authority. Milgram (1963) set to investigate whether ordinary people will obey a legitimate authority figure, even when required to injure other someone (electric shocks). The findings of the study suggest that ordinary people are astonishingly obedi ent to authority when asked to behave in an inhumane manner. Gradual commitment, agentic reposition and the role of buffers are explanations to why people obey (in terms of Milgrams study). As participants have already given lower-level shocks, it becomes harder to resist the experimenters requirement to increase the shocks. Having affiliated themselves to a particular course of action (giving shocks), it becomes difficult for participants to change their mind. native to Milgrams explanation of obedience is what he termed the agentic state, by which he meant, the condition the somebody is in, when he sees himself as an agent to carrying out another persons wishes. Milgram, 1974 (cited in Card, 2005) argued that people move between an agentic state and an autonomous state (state a person is when they see them self acting on their own. Entering an authority system, Milgram claimed the individual no longer views themselves as acting out of his own use but sees themselves as agents f or another.In Milgrams classic study into obedience, the teacher and savant were in different rooms, with the teacher protected (buffered) from seeing his victim. When the learner was in the same room, this buffering effect was reduced. The role of buffers/buffering effect is similarly used to inform the apparent willingness to dispatch weapons of mass destruction (Solomon, Mikulincer, and Hobfoll, 1986). Milgrams research has been quite controversial however, it can be argued that the great value of this research, in helping us understand obedience to authority, justifies the deception and the distress caused to the teachers.Society itself can influence the behaviour of people in many ways. It can pass laws by governmental establishments, develop a strong desire for ethics and morals, check off its professionals to strong ethical codes of conduct, educate and inform through school systems and the media. only if the primary reason why a society can instruction the behaviour of most people is our innate psychological need for transcendent growth and maturity. There seems to be a natural preference at heart the human psyche to behave in a moral or ethical manner. (Schueler, 1997). To conclude, there is evidence to suggest people are in fact aware of social influences whether it is majority and minority effects or obedience to authority people yield to such influences for a variety of reasons normative and informational influence, group identification, social cryptoamnesia, gradual commitment, agentic shift and the role of buffers nevertheless, social psychologists continue to argue that people are often unaware of the influences on their behaviour, thoughts and emotions. (Nisbett Wilson, 1977)

Gender Inequality in Business

Gender In impactity in BusinessIn todays business world, there has been a lot of change in the add of women participating in the labor force. For the past years, the number of women in the break awayforce rises dramatically. Unfortunately, women ar still being treated lower than men when canvas their net profits, and grammatical gender inequalities in the body of work tolerate been very considerable. Women continue to put one across considerably less(prenominal) than men, even though they be in the aforementioned(prenominal) occupations as men. Most of them dont have convincing reason why they are paying less to women the just now reason clarification that can be given for this income gap is inequality. Gender preconceptions in the workplace are wild assumptions and should not be continued because women are just as efficient as men are in doing a parturiency and gender equality is beneficial to workplaces. As a female myself, I very advise women to prepare to addres s the challenges and prepare to meet a a few(prenominal) challenges to their success.In recent decades, women have graduated from college in greater song than men. Therefore, it would seem that there are women who are as qualified as men if not more than. Women should not be treated as less than men, mainly when they have the homogeneous potential and greetledge to do work as the men. According to a 2015 study by Institution For Womens policy Research showed that, on average, female full-time, year-round workers made only 80 cents for every dollar earned by men, a gender wage gap of 20 percent. This record seems unfavorable for women when both males and females are doing the same amount of work for the workplace. I personally think that to have women who adhere paid less than men is illogical, acknowledging the fact that women are earning more degrees. I think the gender discrimination in the workplace is not only leaving women playless, but also affecting the business tha t could gain more benefit from educated and passionate women.Gender inequality in the workplace is the main reasons why womens jobs ofttimes have lower pay and status. Women are less probably to have higher paying professional, technical, and managerial jobs. Women usually have a much greater representation in secretarial and service positions. They knocked turn up(p)numbered men in office jobs in, even though a relatively small percentage of women are in the labor force. For so many reason women are less likely to be promoted to the job with a higher wage, even if they are qualified the same as the men. Part of this inequity is accounted for by the responsibilities that women have at home. Family and home commitments often limit the time, and energy women can devote to work, which makes them appear less commit or competent than men, who can spend more time at their jobs.To start a new job with gender inequality in the workplace could significantly affect womens motivation to ac hieve their task in a correct way. I advise to women beginning a move in business to develop dialogue achievements stand to speak out against the gender discrimination for their benefit and others. As an employee, they should have to understand the police force in place to prevent discrimination in the workplace. An example is an equal pay, discrimination based on their gender.Negotiation is a part of chance(a) life whether we are aware of it or not, we all negotiate for the intimacy we want. For example, people may negotiate to get higher salaries, bump service, and for so many different reasons. In most case women afraid to negotiate, because they call up that there will be a amicable backlash against them. However, negotiation skills help to ensure that all parties are equally advantaged from the inequality that occurs. endlessly women have to prepare for any negotiation. unmatchable of the keys to any negotiation is to do research on the restoration in order to devel op your strategy. I advise that women should improve their negotiating skills by practicing objectivity. I encourage women to do round research about the job that gets offered before they accept the job. We all know many companies pays less money for women than men for doing the same job. First, research the marketplace and be aware what your skills and knowledge are worth. The more knowledge or information you get from you research will help to you to decide wisely and will also give you the chance to become a better negotiator.The second thing I would like to advise is to speak out loud against the gender discrimination. I believe women are naturally sharp for networking and skilled in building communities. Today, many people use social media for different purposes, and it seems to play a crucial part of peoples lives around the world. I think many women can use the social media to promote the discrimination and business at lower cost with high target impact.In conclusion, gend er inequalities in workplaces are rough in contemporary ball club and are illogical. Numerous studies support that women are capable of doing a task as well as a male can, and even acting better than them. There are so many reasons that show that the issue of gender discrimination in the workplace is significant and negatively impacting. One of the disadvantages working in a place with gender inequality could have a high impact on womens motivation. Second, gender discrimination or inequality in the workplace could affect the effectiveness of the companys corporate. Therefore, to solve gender discrimination in the workplace, everyone has to take responsibility. Womens have to develop their negotiation skill and to speak out loud for their right. Further, Companies should give the opportunities equally to everyone without any isolation.

Racism in Deadly Unna by Phillip Gwynne Essay example -- essays resear

Deadly Unna Deadly Unna is the story of Garry Blacks realization of racialism and discrimination in the expression where he lives. When everyone else seems do nonhing to go along the discrimination Blacky a young boy steps up to the central office and has the guts to say no against racism towards the local Aborigines. Blacky is beginning to score that the spate he looks up to as role models might non be such good examples as most of them including his father his footy motorbus and even the pub custodian all accept racism as a normal way of life and Blacky begins to realize this and tries to make them aware. At the beginning Blacky becomes aware of the apartheid of white and black first in the players at the local footy police squad, the white players (Goonyas) all got changed at one final stage of the gild change rooms while the Aboriginal (Nunga) players got changed at the opposite end ?Usually the nungas got changed at one end us goonyas got changed at th e separate? pg. 21. This is when Blacky begins to realize that even though he sees everyone as equal the emit of the town does not necessarily feel the same. Even Blackys friend Pickles encourages in a way Blacky not to be Dumbys friend, Blacky goes along with it only when in the end admits to his friendship with Dumby red, ? Mate of yours now is he? (Pickles) No way not him I hate his guts (Blacky)?pg. 25 after he verbalize this he spat on the ground to prove to Pickles that he meant it Blacky had not realized that his friend were so racist and had previously gone along with any racist slurs they made. His suspicions were confirmed when, at the grand final show Mark ?Arks? won the Mcrae medal instead of Dumby red. Dumby had been the heart and soul of the team all season and deserved to win h... ...rn because he specifically told Blacky that he was to go fishing with him and nowhere else. Despite his strong feelings for Cathy Blacky even misses pop on going to Kathy barbie on her last day in the port this is (to the best of blackys knowledge) the last chance he will have to single out her how he feels about her, despite this he gets up at come home and walks for three hours to reach the mission. In conclusion Black?s request to make people aware of racism in the port got him into a lot of strife but he did manage to show people that he did not in any way condone this var. of discrimination and took a stand against the way the entire town supposition forcing them to think about their actions. in the end the people that Garry most touch were his brothers and sisters , he may not have changed the whole towns attitude but he taught his siblings a priceless life lesson.

The Drinking Age Should Not Be Lowered Essay example -- MLDA, Underag

We knocked on the door of the off-campus apartment, as it opened we were confronted with the heavy stench of alcohol. A puppyish girl was passed out on the living room floor, a chew of empty beer cans filled the kitchen sink, and the deafening music rattled the window panes. A group of girls man seasond to stumble past us. They waved goodbye to the host, who was handing drinks to me and my sister. It was not my first cartridge holder drinking. In fact, everyone there was quite experienced after all, its college. fractional of the guests were completely drunk, and I had no problem with it. That is, until later that night when my sister locked herself in a room with a guy she had met only a week before. This prompted me to seriously consider the effects of alcohol. Would my sister birth been equal to see the danger of the situation had she been sober? Would the absence of alcohol have prevented the events of that night from occurring? These questions, along with the vivid mem ory of that night, fueled my examination of the labyrinthian social problem of under progress drinking. In the 1960s, the drinking age was machinate as 21, to match the voting age. However, around the time of the Vietnam War, the public began to grapple that if an 18-year-old was old enough to fight and die for his country, then he should be able to vote as well. As a result, the voting age was lowered to 18. Between 1970 and 1976, 29 states lowered their profound drinking age as well. In the words of Carla Main, author of Bulldozed and various other produce works concerning law and society, the results were catastrophic, as highway deaths among teenagers and young adults skyrocketed (Main 33). Many states began raising the legal drinking age up again. In 1984, under the supervision of Ronald ... ...hus, focalization should be on better enforcing the law, rather than amending it. Works CitedDeJong, William. Should the crapulence fester Be Lowered to 18? No. American Teacher 93.3 (2008) 3. Wilson OmniFile total Text Mega Edition. Web. 3 Mar. 2010.Main, Carla T. Underage Drinking and the Drinking Age. Policy Review. June/July 2009 33-46. Wilson OmniFile secure Text Mega Edition. Web. 3 Mar. 2010.Martinez, Julia A., Miguel A. Munoz Garcia, and Kenneth J. Sher. A New Minimum Legal Drinking Age (MLDA)? Some Findings to Inform the Debate. Addictive Behaviors 34.4 (2009) 407-10. Wilson OmniFile Full Text Mega Edition. Web. 3 Mar. 2010.Muhlenfeld, Elisabeth. Seeking a Drinking Age Debate. University Business 11.10 (2008) 53-4. Academic reckon Premier. Web. 3 Mar. 2010. The 21 Club. Economist 392.8645 (2009) 26. Academic Search Premier. Web. 3 Mar. 2010.

Essay --

In 1861, conflicts and tensity between the northern and southern join States erupted into the Civil state of war, the bloodiest war in American history. Economic differences existed between the north and south, which made the Civil War inevitable. The souths economy was largely agriculturally based and dependent on knuckle down labor, while the north was much industrial and based on poerty-stricken labor. The issue of slavery is often cited as the main set about of the Civil War, but it is truly the economic dependency of the South on slavery that caused the Civil War. Slavery being the backbone of the South conduct to conflict on whether or not states should be admitted as free or slave states, which could potentially tip the balance of free states vs slave states representation in the Senate. The North and South being so radically different in economy and culture created conflict between them. Their differences actually made the Civil War an inevitable event, because as t he saying goes, United we stand, divided we fall. Their differences divided the country, ultimately leading to the Civil War. first from the end of the American Revolution, the north had developed differently than the south. This was largely payable to differences in geography. There were more seaports in the north, and factories became more prevalent. A commercial-grade economy resulted. Roads and canals were built, and cities grew. Many people were merchants, manufacturers, lawyers, and salesmen. The north became more and more metropolitan. There were still farmers living in the north, but they differed from southern farmers in that they used more modern technology to farm and became more efficient. land was easier in the north than the south as well, because of the souths serious ... ...t states, Upon the whole, therefore, it is the brain of this court, that it appears by the record before us that the plaintiff in error is not a citizen of Missouri, in the sense in which that pronounce is used in the Constitution and that the Circuit Court of the United States, for that reason, had no jurisdiction in the case, and could give no judgment in it. Its judgment for the defendant must, consequently, be reversed, and a mandate issued, directing the suit to be dismissed for want of jurisdiction. This meant that Scott was not considered a citizen, so he had no rights, could not sue, and had to remain a slave. The court further ruled that forbidding slavery was unconstitutional, since slaves were property and property is protected under the Constitution.The controversy over slavery was intensified,and further deepened the rift between the north and the south.

Platos Meno :: essays research papers

     The questions of what exactly experience, virtue and the soul are, are among the most important problems of school of thought The soul may be defined as the ultimate inside principle by which we think, feel, and exist. If there is life after death, the soul essential be capable of an existence separate from the body. The mysteries of birth and death, the lapse of sensible life during sleep, even the most common operations of imagination and memory, which rise a man from his bodily presence even while arouse all such facts suggest the existence of some involvement other. The quest to put a solid definition on what exactly association and virtue was the footing of Socrates life. Socrates discusses these things all the time but they seemed to be better explained in two specific dialogues The Meno and The Republic.     In the Meno, Plato justifies the possibility for ones mind to uncover knowledge. Plato presents a well-grounded th eory on how our minds can obtain knowledge. Socrates asks What is virtue? , when questioning Meno on the single definition of virtue, Socrates was never satisfied. He never accepted Menos answers because Meno gave virtuous definitions, non the definition of virtue. For example, Meno claimed, A mans virtue, consists of being able to sway public affairs and in so doing to benefit his friends and harm his enemies and to be careful no harm comes to himself." Meno does not know what virtue rightfully is, so he cannot apply which characteristics associate with virtue and which do not. So when Socrates asks, Does anyone know what a part of virtue is, without knowing the whole?, Meno agrees this is not possible. This presents a logical argument against Menos definition of virtue. Socrates believes the conversation to pursuit for what virtue really is should continue although they achieved no success in their prototypical effort to form a definition. Meno questions Socrates, And how will you inquire, into that of which you are totally stupid? What sort of thing, among those things which you know not, will you put forth as the target area of your seeking? And even if you should chance upon it, how will you ever know that it is the thing which you not know?. Socrates explores the subject that one not only obtains knowledge through perception but can also obtain knowledge through reason and hard work. Socrates then tells Meno of the theory of recollection.

Charles Dickens :: GCSE English Literature Coursework

Charles demon (1812-1870) is one of the greatest and roughly popular writers in the history of literature. In his novels, daimon combines masterly storytelling, humor, pathos, and irony with sharp social criticism and groovy observation of people and places, both real and imagined. On February 7, 1812, in Portsmouth, England, Charles Dickens was born to John and Elizabeth Dickens. Charles was the second of eight children. He spent most of his childhood in London, the setting for many of his novels. He lived in a middle-classed family that, but his father was incapable of managing his own finances. Dickens started school at the age of nine, but his education was interrupted when his father was imprisoned for debt in 1824. He was then forced to work at Warrens Blacking Factory, a shoe-polish factory, to support himself. His experiences of trying to survive in the slums of England pursue him all of his liveliness, and he would later devote many of his books to the retelling of hi s experiences. Dickens was save from this situation when his father was released from prison. From 1825 to 1827, Dickens again attended school for devil years of formal schooling at Wellington House honorary society in Hamstead. For the most part, however, he was self-educated. In 1827, demon took a transaction as a legal clerk. By 1829, he had become a free-lance newsperson at Doctors Commons Courts. He had become a very successful shorthand reporter of parliamentary debates in the House of Commons and began work as a reporter for a newspaper, in 1832. During his time as a reporter he would develop his skills to write very detailed and factual-like stories.In 1833, Dickens create his first of a series of original descriptive sketches of daily life in London. By 1834, he and adopted the pseudonym Boz. His Sketches by Boz was promulgated in 1836. During that year he would marry Catherine Hogarth on April 2, 1836.In 1836, Charles dickens published his first novel The Posthumous document of the Pickwick Club. The success of the Pickwick Papers made him famous. At the same time it influenced the publishing industry in Great Britain, being issued in an unusual form, that of inexpensive monthly installments that would set out in literary magazines.